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This report from the Girls at the Margin National Alliance, co-authored by the Initiative as a steering committee member of the Alliance, highlights the systemic harms experienced by girls and offers solutions to support girls and gender-expansive young people so that they may lead full and complete lives. The report offers insight and policy recommendations across nine core areas including, child welfare, sex trafficking, gender violence, education, immigration, pregnant and parenting youth, the legal system, runaway and homeless youth, and health and healing.